This volume (162 pages) contains medical essays composed at the Pennsylvania Hospital in Philadelphia in 1849 and 1850, as well as drafts of letters composed in 1878 and 1879. The first 99 pages consist of medical notes and essays written during Carson's final year studying medicine at the University of Pennsylvania, including reports on medical cases, information on ailments and medicines, and notes concerning surgical operations. Essays on ailments and medicines (pages 100-159) focus on symptoms and relief, and include several based on particular types of medicines, such as diuretics and expectorants. Other essays examine the effects of the medicines on the body. The volume also contains medicinal recipes (pp. 160-161). Several doctors are mentioned, including H. S. Patterson, Joseph Carson, G[eorge] B. Wood, and Henry H. Smith. The medical content dates from March 15, 1849, to January 1850, and covers most of the volume's odd-numbered pages, with additional content appearing on some even-numbered pages, including several rough sketches of generic human figures that appear on the inside of both covers and throughout the book, and a series of indexes of miscellaneous words. Some additional items are signatures for residents of several towns in New York, a poem entitled "Buccaneer Bride" (p. 42), recipes for breakfast rolls and doughnuts (pp. 46, 48), household accounts for decorative items, and drafts of letters. Of the letters, one is signed by Grace Burton of Millport, New York. Addie A. McCurdy, also of Millport, New York, occasionally signed her name on some of the even-numbered pages.