The Perkins family papers comprise 177 letters and 2 compositions, which date 1807-1861, as well as a memorial book, published in 1891, containing biographical information on Benjamin and Jane Perkins.,
The majority of the collection is composed of correspondence between Benjamin Perkins, his wife Jane, and their family members, particularly Jane's parents and the couple's children. Between 1835 and 1850, the family exchanged approximately 120 letters on a number of topics. In addition to sharing a great deal of detailed family news, many letters discuss education and reading; in his letter of December 28, 1840, Benjamin wrote to his son, Charles, "I feel very desirous that you should be in the habit of having some useful book in hand always, altho' you are not able to read much at a time." Mary described her boarding school, on June 14, 1841. Additional items mention lectures by geologist Charles Lyell at the Lowell Institute (October 19, 1841), the publishing business (January 27, 1842), and travel to New York City and Philadelphia.
Religion is also a frequent subject of the collection's correspondence, and many letters mention church attendance, charitable societies, and missionaries. On April 12, 1842, Mary Perkins wrote a letter concerning minister Edward Norris Kirk's visit to Roxbury and the crowds that he attracted, and stated "I like him a great deal better than any minister I ever heard before, and should be as happy as could be if he would settle here." Also included in the collection are several letters written by Thomas S. Childs, prominent clergyman and future husband of Jane Perkins. In a letter of August 1, 1845, he discussed the situation of a minister whose congregation was "equally divided in regard to his remaining" because of his abolitionist tendencies.
This collection was originally thought to be related to the William and Isaac Perkins papers, but no connection between the two families has been found.