Issue in Honor of Prof. Vincenzo Tortorella ARKIVOC 2004 (v) 54-65
Glyceroglycolipids from Euphorbia nicaeensis All. with antiinflamatory activity
Francesca Cateni*a, Gioacchino Falsonea, Jelena Zilica, Paolo Boniventoa, Marina Zacchignaa, Dušan Žigonb, Silvio Sosac, and Gianmario Altinierc
a Department of Pharmaceutical Sciences, University of Trieste, P.zle Europa 1, 34127 Trieste, Italy b Department of Environmental Sciences, “Jožef Stefan” Institute, Jamova 39, 1000 Ljubljana, Slovenia c DEMREP, University of Trieste, Via A. Valerio 6, 34127 Trieste E-mail: cateni@univ.trieste
In honour of Professor Vincenzo Tortorella in the occasion of his " Fuori Ruolo " status (received 06 Nov 03; accepted 15 Jan 04; published on the web 21 Jan 04)
Abstract
Two new glyceroglycolipids as well as three known ones were isolated from the glyceroglycolipids molecular species obtained from two less polar fractions of the MeOH extract of the plant Euphorbia nicaeensis All. using normal and reversed phase column flash chromatography. The structures of the isolated glyceroglycolipids were determined on the basis of chemical and spectroscopic evidences. Two new glyceroglycolipids were isolated for the first time from Euphorbiaceae, 2 was assigned as (2S)-2,3-O-di-(hexadecanoyl)-glyceryl-ß-D-galactopyranoside and 5 as (2S)-3-O-(9, 12octadecadienoyl)- glyceryl-ß-D-galactopyranoside. The isolated glyceroglycolipids exhibited an interesting anti-inflammatory activity.
Keywords: Euphorbia nicaeensis All, plant, glyceroglycolipids, anti-inflammatory activity
Introduction
Euphorbiaceae plants are well known to contain irritant and tumor-promoting constituents.1 In particular, diterpenoids from the Euphorbiaceae have been found to possess interesting biological activities.2 Euphorbia nicaeensis All. is a hardy perennial which inhabits sandy coasts and shingle beaches and is native to the entire Mediterranean region.
Chemical constituents of this species have been investigated previously and the presence of tetracyclic triterpenoids as well as sphingolipids has been reported.3,4 Extracts of the roots of
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